Health & Wellness
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科学家揭示致命真菌的关键弱点,为新治疗方法铺平道路

2025年12月23日發表的研究結果可能會帶來新的治療方法,或允許目前的藥物被重新利用,為一種難以控制且幾乎不可能治癒的病原體帶來早期希望。該研究的首席研究員艾瑪·泰勒博士(Dr. Emma Taylor)解釋說,研究團隊的突破來自於開發了一個模擬白色念珠菌(Candida auris)感染人體條件的活體宿主模型。 「透過觀察真菌的活動,我們能夠找出它激活的特定基因,以搜尋營養,這可能是開發新治療方法的關鍵」,她說。

白色念珠菌是一種罕見但致命的真菌感染,已經與世界各地的醫院爆發相關聯。這種真菌尤其令人擔憂,因為它幾乎對所有抗真菌藥物都有耐藥性,使其難以治療。根據疾病控制和預防中心(CDC)的資料,白色念珠菌已經在美國 alone 引起至少600例報告病例,導致大量死亡。

對白色念珠菌的基因機制的發現可能會對治療這種致命真菌產生重大影響。羅格斯新澤西醫學學校(Rutgers New Jersey Medical School)的首席科學官大衛·珀林博士(Dr. David Perlin)指出,研究結果可能會帶來新的抗真菌治療方法的開發。 「這是對白色念珠菌的理解的一個重大突破,它可能會帶來更有效的治療方法」,他說。

研究結果目前正在由科學界審查,需要進一步的研究來確認結果並開發新的治療方法。然而,對白色念珠菌的基因機制的發現為患者和醫療保健專業人員帶來了一絲希望,他們一直在努力對抗這種致命的真菌。正如泰勒博士所說,「這是在我們對抗白色念珠菌的戰鬥中的一個重要步驟,我們渴望繼續探索這一發現的潛力,以改善患者的治療效果」。

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